Cognitive impairment in coeliac disease improves on a gluten-free diet and correlates with histological and serological indices of disease severity

Highlights: Eleven adult patients that recently started a gluten-free diet after celiac disease diagnosis were followed over one year – including histology (upper GI biopsy results), serology (blood tTG antibody), serum micronutrients and cognitive function measurements. Cognitive function was impaired at the beginning of the study, but all cognitive function measurements improved over the year (several of the measurements showed statistically significant improvement). Cognitive improvement correlated with histology and serology improvement, but not serum micronutrients.

Application to Dietetic Practice: Celiac patients often complain of brain fog prior to treatment with a gluten-free diet. This pilot study provides preliminary support for this manifestation and potentially demonstrates the importance of a gluten-free diet. When counselling celiac clients on the importance of following a strict gluten-free diet, improved cognitive function can be discussed (particularly for clients that report cognitive impairment). The authors indicate that additional, larger studies are planned on this topic.

Pub Med ID: 24889390

Posted in: Summer2015-Research